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gcpm animal model  (Galectin Therapeutics)

 
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    Structured Review

    Galectin Therapeutics gcpm animal model
    Galectin-1 promotes <t>GCPM</t> through <t>the</t> <t>TGF-β/Smad</t> signaling pathway (A) Representative images of the GCPM animal model established in this study. (B) H&E staining confirmed that the peritoneal nodules were metastatic carcinomas (×400 magnification). (C–E) Representative immunofluorescence images of E-cadherin and vimentin (C), TGF-β1 (D) and p -Smad2/3 (E) in the peritoneum of model animals (×400 magnification). (F) The PCI of mice in different groups ( n = 6). (G and H) The mean fluorescence density of vimentin and E-cadherin ( n = 6). (I and J) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01, NS, p > 0.05.
    Gcpm Animal Model, supplied by Galectin Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gcpm+animal+model/pmc13206751-178-13-0?v=Galectin+Therapeutics
    Average 86 stars, based on 1 article reviews
    gcpm animal model - by Bioz Stars, 2026-08
    86/100 stars

    Images

    1) Product Images from "Gastric cancer-secreted galectin-1 promotes peritoneal mesothelial-mesenchymal transition to prime peritoneal metastasis soil"

    Article Title: Gastric cancer-secreted galectin-1 promotes peritoneal mesothelial-mesenchymal transition to prime peritoneal metastasis soil

    Journal: iScience

    doi: 10.1016/j.isci.2026.115908

    Galectin-1 promotes GCPM through the TGF-β/Smad signaling pathway (A) Representative images of the GCPM animal model established in this study. (B) H&E staining confirmed that the peritoneal nodules were metastatic carcinomas (×400 magnification). (C–E) Representative immunofluorescence images of E-cadherin and vimentin (C), TGF-β1 (D) and p -Smad2/3 (E) in the peritoneum of model animals (×400 magnification). (F) The PCI of mice in different groups ( n = 6). (G and H) The mean fluorescence density of vimentin and E-cadherin ( n = 6). (I and J) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01, NS, p > 0.05.
    Figure Legend Snippet: Galectin-1 promotes GCPM through the TGF-β/Smad signaling pathway (A) Representative images of the GCPM animal model established in this study. (B) H&E staining confirmed that the peritoneal nodules were metastatic carcinomas (×400 magnification). (C–E) Representative immunofluorescence images of E-cadherin and vimentin (C), TGF-β1 (D) and p -Smad2/3 (E) in the peritoneum of model animals (×400 magnification). (F) The PCI of mice in different groups ( n = 6). (G and H) The mean fluorescence density of vimentin and E-cadherin ( n = 6). (I and J) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01, NS, p > 0.05.

    Techniques Used: Animal Model, Staining, Immunofluorescence, Fluorescence

    Inhibition of TGF-β1 attenuates peritoneal MMT and suppresses GCPM (A) Schematic representation of the carcinomatosis models. (B) Representative gross images of peritoneal carcinomatosis and corresponding H&E staining (×400 magnification). (C) PCI across experimental groups ( n = 6). (D–F) Representative immunofluorescence images showing expression of TGF-β1, p -Smad2/3, and E-cadherin/vimentin in peritoneal tissues from model mice (×400 magnification). (G and H) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). (I and J) Mean fluorescence density of vimentin and E-cadherin ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01.
    Figure Legend Snippet: Inhibition of TGF-β1 attenuates peritoneal MMT and suppresses GCPM (A) Schematic representation of the carcinomatosis models. (B) Representative gross images of peritoneal carcinomatosis and corresponding H&E staining (×400 magnification). (C) PCI across experimental groups ( n = 6). (D–F) Representative immunofluorescence images showing expression of TGF-β1, p -Smad2/3, and E-cadherin/vimentin in peritoneal tissues from model mice (×400 magnification). (G and H) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). (I and J) Mean fluorescence density of vimentin and E-cadherin ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01.

    Techniques Used: Inhibition, Staining, Immunofluorescence, Expressing, Fluorescence



    Similar Products

    gcpm animal model  (Galectin Therapeutics)
    86
    Galectin Therapeutics gcpm animal model
    Galectin-1 promotes <t>GCPM</t> through <t>the</t> <t>TGF-β/Smad</t> signaling pathway (A) Representative images of the GCPM animal model established in this study. (B) H&E staining confirmed that the peritoneal nodules were metastatic carcinomas (×400 magnification). (C–E) Representative immunofluorescence images of E-cadherin and vimentin (C), TGF-β1 (D) and p -Smad2/3 (E) in the peritoneum of model animals (×400 magnification). (F) The PCI of mice in different groups ( n = 6). (G and H) The mean fluorescence density of vimentin and E-cadherin ( n = 6). (I and J) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01, NS, p > 0.05.
    Gcpm Animal Model, supplied by Galectin Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gcpm+animal+model/pmc13206751-178-13-0?v=Galectin+Therapeutics
    Average 86 stars, based on 1 article reviews
    gcpm animal model - by Bioz Stars, 2026-08
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    Galectin-1 promotes GCPM through the TGF-β/Smad signaling pathway (A) Representative images of the GCPM animal model established in this study. (B) H&E staining confirmed that the peritoneal nodules were metastatic carcinomas (×400 magnification). (C–E) Representative immunofluorescence images of E-cadherin and vimentin (C), TGF-β1 (D) and p -Smad2/3 (E) in the peritoneum of model animals (×400 magnification). (F) The PCI of mice in different groups ( n = 6). (G and H) The mean fluorescence density of vimentin and E-cadherin ( n = 6). (I and J) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01, NS, p > 0.05.

    Journal: iScience

    Article Title: Gastric cancer-secreted galectin-1 promotes peritoneal mesothelial-mesenchymal transition to prime peritoneal metastasis soil

    doi: 10.1016/j.isci.2026.115908

    Figure Lengend Snippet: Galectin-1 promotes GCPM through the TGF-β/Smad signaling pathway (A) Representative images of the GCPM animal model established in this study. (B) H&E staining confirmed that the peritoneal nodules were metastatic carcinomas (×400 magnification). (C–E) Representative immunofluorescence images of E-cadherin and vimentin (C), TGF-β1 (D) and p -Smad2/3 (E) in the peritoneum of model animals (×400 magnification). (F) The PCI of mice in different groups ( n = 6). (G and H) The mean fluorescence density of vimentin and E-cadherin ( n = 6). (I and J) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01, NS, p > 0.05.

    Article Snippet: Galectin-1 promotes GCPM through the TGF-β/Smad signaling pathway (A) Representative images of the GCPM animal model established in this study. (B) H&E staining confirmed that the peritoneal nodules were metastatic carcinomas (×400 magnification). (C–E) Representative immunofluorescence images of E-cadherin and vimentin (C), TGF-β1 (D) and p -Smad2/3 (E) in the peritoneum of model animals (×400 magnification). (F) The PCI of mice in different groups ( n = 6). (G and H) The mean fluorescence density of vimentin and E-cadherin ( n = 6). (I and J) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6).

    Techniques: Animal Model, Staining, Immunofluorescence, Fluorescence

    Inhibition of TGF-β1 attenuates peritoneal MMT and suppresses GCPM (A) Schematic representation of the carcinomatosis models. (B) Representative gross images of peritoneal carcinomatosis and corresponding H&E staining (×400 magnification). (C) PCI across experimental groups ( n = 6). (D–F) Representative immunofluorescence images showing expression of TGF-β1, p -Smad2/3, and E-cadherin/vimentin in peritoneal tissues from model mice (×400 magnification). (G and H) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). (I and J) Mean fluorescence density of vimentin and E-cadherin ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01.

    Journal: iScience

    Article Title: Gastric cancer-secreted galectin-1 promotes peritoneal mesothelial-mesenchymal transition to prime peritoneal metastasis soil

    doi: 10.1016/j.isci.2026.115908

    Figure Lengend Snippet: Inhibition of TGF-β1 attenuates peritoneal MMT and suppresses GCPM (A) Schematic representation of the carcinomatosis models. (B) Representative gross images of peritoneal carcinomatosis and corresponding H&E staining (×400 magnification). (C) PCI across experimental groups ( n = 6). (D–F) Representative immunofluorescence images showing expression of TGF-β1, p -Smad2/3, and E-cadherin/vimentin in peritoneal tissues from model mice (×400 magnification). (G and H) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6). (I and J) Mean fluorescence density of vimentin and E-cadherin ( n = 6). Data are represented as mean ± SD. ∗∗ p < 0.01.

    Article Snippet: Galectin-1 promotes GCPM through the TGF-β/Smad signaling pathway (A) Representative images of the GCPM animal model established in this study. (B) H&E staining confirmed that the peritoneal nodules were metastatic carcinomas (×400 magnification). (C–E) Representative immunofluorescence images of E-cadherin and vimentin (C), TGF-β1 (D) and p -Smad2/3 (E) in the peritoneum of model animals (×400 magnification). (F) The PCI of mice in different groups ( n = 6). (G and H) The mean fluorescence density of vimentin and E-cadherin ( n = 6). (I and J) The relative fluorescence density of TGF-β1 and p -Smad2/3 ( n = 6).

    Techniques: Inhibition, Staining, Immunofluorescence, Expressing, Fluorescence